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Literature summary for 4.2.1.24 extracted from

  • Tang, L.; Breinig, S.; Stith, L.; Mischel, A.; Tannir, J.; Kokona, B.; Fairman, R.; Jaffe, E.K.
    Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins) (2006), J. Biol. Chem., 281, 6682-6690.
    View publication on PubMed
Search for more literature for 4.2.1.24

Protein Variants

Protein Variants Comment Organism
R240A mutant enzyme assembles into a metastable hexamer, which can undergo a reversible conversion to the octamer in the presence of substrate Homo sapiens
R240AS metastable nature of the R240A hexamer Homo sapiens
W19A assembles into a mixture of stable dimers Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
69600
-
 mutant enzyme W19A, pH 7, analytical ultracentrifugation Homo sapiens
78600
-
 mutant enzyme W19A, pH 7, dynamic light scattering Homo sapiens
183500
-
 mutant enzyme R240A, pH 9, analytical ultracentrifugation Homo sapiens
188500
-
 mutant enzyme R240A, pH 7, analytical ultracentrifugation Homo sapiens
197900
-
 mutant enzyme F12L, pH 7, analytical ultracentrifugation Homo sapiens
212400
-
 mutant enzyme R240A, pH 7, dynamic light scattering Homo sapiens
214400
-
 mutant enzyme F12L, pH 7, dynamic light scattering Homo sapiens
244000
-
 wild-type enzyme, pH 7, analytical ultracentrifugation Homo sapiens
317600
-
 wild-type enzyme, pH 7, dynamic light scattering Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P13716
-
-

Subunits

Subunits Comment Organism
octamer the enzyme is an obligate oligomer that can exist in functionally distinct quaternary states of different stoichiometries, which are called morpheeins, human PBGS assembles into long-lived morpheeins and is capable of forming either a high activity octamer or a low activity hexamer Homo sapiens

Synonyms

Synonyms Comment Organism
PBGS
-
 Homo sapiens