Literature summary for 4.2.1.24 extracted from

Komai, H.; Neilands, J.B.
The metalloprotein nature of Ustilago delta-aminolevulinate dehydratase (1969), Biochim. Biophys. Acta, 171, 311-320.

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Activating Compound

Activating Compound	Comment	Organism	Structure
thiol	required	Ustilago sphaerogena

Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Ustilago sphaerogena
2,2'-dipyridine	-	Ustilago sphaerogena
8-hydroxyquinoline	-	Ustilago sphaerogena
bathocuproine disulfonic acid	i.e. 2,9-dimethyl-4,7-diphenyl-1,10-phenanthrolinedisulfonate	Ustilago sphaerogena
Cuprizone	bis-cyclohexanoneoxaldihydrazone	Ustilago sphaerogena
diethyldithiocarbamate	-	Ustilago sphaerogena
EDTA	-	Ustilago sphaerogena
KCN	-	Ustilago sphaerogena
Neocuproine	2,9-dimethyl-1,10-phenanthroline	Ustilago sphaerogena

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	partially restores enzyme after inactivation of 2,9-dimethyl-4,7-diphenyl-1,10-phenanthrolinedisulfonate	Ustilago sphaerogena
Zn2+	restores enzyme after inactivation by 2,9-dimethyl-4,7-diphenyl-1,10-phenanthrolinedisulfonate	Ustilago sphaerogena

Organism

Organism	UniProt	Comment	Textmining
Ustilago sphaerogena	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Ustilago sphaerogena

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Ustilago sphaerogena

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-aminolevulinate + 5-aminolevulinate	-	Ustilago sphaerogena	porphobilinogen + 2 H2O	-	?

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Release 2023.1 (January 2023)