Literature summary for 4.2.1.22 extracted from

Mendes, M.I.; Colaco, H.G.; Smith, D.E.; Ramos, R.J.; Pop, A.; van Dooren, S.J.; Tavares de Almeida, I.; Kluijtmans, L.A.; Janssen, M.C.; Rivera, I.; Salomons, G.S.; Leandro, P.; Blom, H.J.
Reduced response of cystathionine beta-synthase (CBS) to S-adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in homocystinuria patients (2014), J. Inherit. Metab. Dis., 37, 245-254.

Search for more literature for 4.2.1.22

Activating Compound

Activating Compound	Comment	Organism	Structure
S-adenosyl-L-methionine	the enzyme is allosterically activated (2-3fold) by S-adenosyl-L-methionine	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D444N	the mutant shows 97% activity compared to the wild type enzyme when expressed in Escherichia coli	Homo sapiens
I278T	the mutant shows 0.7% activity compared to the wild type enzyme when expressed in Escherichia coli	Homo sapiens
P427L/S500L	the mutant is almost not activated by S-adenosyl-L-methionine	Homo sapiens
P49L	the mutant shows 39% activity compared to the wild type enzyme when expressed in Escherichia coli	Homo sapiens
R336H	the mutant shows 0.43% activity compared to the wild type enzyme when expressed in Escherichia coli	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-serine + L-homocysteine	Homo sapiens	-	L-cystathionine + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-serine + L-homocysteine	-	Homo sapiens	L-cystathionine + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CBS	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)