Activating Compound | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | the enzyme is allosterically activated (2-3fold) by S-adenosyl-L-methionine | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D444N | the mutant shows 97% activity compared to the wild type enzyme when expressed in Escherichia coli | Homo sapiens |
I278T | the mutant shows 0.7% activity compared to the wild type enzyme when expressed in Escherichia coli | Homo sapiens |
P427L/S500L | the mutant is almost not activated by S-adenosyl-L-methionine | Homo sapiens |
P49L | the mutant shows 39% activity compared to the wild type enzyme when expressed in Escherichia coli | Homo sapiens |
R336H | the mutant shows 0.43% activity compared to the wild type enzyme when expressed in Escherichia coli | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + L-homocysteine | Homo sapiens | - |
L-cystathionine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + L-homocysteine | - |
Homo sapiens | L-cystathionine + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CBS | - |
Homo sapiens |