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Literature summary for 4.2.1.22 extracted from

  • Ishikawa, K.; Mino, K.; Nakamura, T.
    New function and application of the cysteine synthase from archaea (2010), Biochem. Eng. J., 48, 315-322.
No PubMed abstract available
Search for more literature for 4.2.1.22

Activating Compound

Activating Compound Comment Organism Structure
S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae
S-adenosyl-L-methionine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + L-homocysteine Aeropyrum pernix
-
 L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine Saccharomyces cerevisiae
-
 L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine Homo sapiens
-
 L-cystathionine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Aeropyrum pernix Q9YCN5 cystathionine beta-synthase
-
Homo sapiens P35520
-
-
Saccharomyces cerevisiae P32582
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + L-homocysteine
-
 Aeropyrum pernix L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine
-
 Saccharomyces cerevisiae L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine
-
 Homo sapiens L-cystathionine + H2O
-
 ?
additional information O-acetylserine sulfhydrylase isozyme A, OASSAp, EC 2.5.1.65, exhibits both O-acetylserine sulfhydrylase and cystathionine beta-synthase activities Aeropyrum pernix ?
-
 ?

Subunits

Subunits Comment Organism
multimer
-
 Saccharomyces cerevisiae
multimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
CBS
-
 Aeropyrum pernix
CBS
-
 Saccharomyces cerevisiae
CBS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Saccharomyces cerevisiae
heme
-
 Homo sapiens
pyridoxal 5'-phosphate
-
 Aeropyrum pernix
pyridoxal 5'-phosphate
-
 Saccharomyces cerevisiae
pyridoxal 5'-phosphate
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism CBS is involved in the cysteine pathway of bacteria and plants, overview Saccharomyces cerevisiae
metabolism CBS is involved in the cysteine pathway of bacteria and plants, overview Homo sapiens
metabolism cystathionine beta-synthase is involved in the cysteine pathway of bacteria and plants, overview Aeropyrum pernix