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Literature summary for 4.2.1.22 extracted from

  • Prathapasinghe, G.A.; Siow, Y.L.; Xu, Z.; O, K.
    Inhibition of cystathionine-beta-synthase activity during renal ischemia-reperfusion: role of pH and nitric oxide (2008), Am. J. Physiol. Renal Physiol., 295, F912-F922.
    View publication on PubMed
Search for more literature for 4.2.1.22

Inhibitors

Inhibitors Comment Organism Structure
additional information the CBS activity is significantly reduced in kidneys subjected to ischemia alone (15-60 min) or subjected to ischemia followed by reperfusion for 1-24 h, injection of alkaline solution into the kidney partially restores the CBS activity during ischemia, reduction of CBS activity during reperfusion is accompanied by an elevation of nitrate and nitrite in the kidney tissue, injection of 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide restores the CBS activity in the kidneys subjected to ischemia-reperfusion Rattus norvegicus
nitric oxide irreversible inhibition Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + L-homocysteine
-
 Rattus norvegicus L-cystathionine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CBS
-
 Rattus norvegicus
cystathionine-beta-synthase
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 10
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate CBS is a pyridoxal 5'-phosphate-dependent enzyme Rattus norvegicus