Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.22 extracted from

  • Taoka, S.; Lepore, B.W.; Kabil, O.; Ojha, S.; Ringe, D.; Banerjee, R.
    Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme (2002), Biochemistry, 41, 10454-10461.
    View publication on PubMed
Search for more literature for 4.2.1.22

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme is more active under oxidizing conditions Homo sapiens
S-adenosyl-L-methionine activates 2fold Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
catalytic core, hanging drop vapor diffusion method Homo sapiens

Protein Variants

Protein Variants Comment Organism
C272A 2fold lower heme content, 2fold lower specific activity, 2fold higher activity in the presence of S-adenosyl-L-methionine Homo sapiens
C274S 2fold lower heme content, 2fold lower specific activity, 2fold higher activity in the presence of S-adenosyl-L-methionine Homo sapiens
additional information deletion mutant CBSdeltaN43/deltaC143 lacking C-terminal and N-terminal amino acids Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P35520
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Serine + homocysteine beta-replacement reaction Homo sapiens Cystathionine + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
heme b-type heme Homo sapiens
pyridoxal 5'-phosphate
-
 Homo sapiens