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Literature summary for 4.2.1.22 extracted from

  • Taoka, S.; West, M.; Banerjee, R.
    Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites (1999), Biochemistry, 38, 2738-2744.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CO reversible competitive with respect to homocysteine, complete loss of activity at 0.06 mM Homo sapiens
cyanide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Serine + homocysteine
-
Homo sapiens Cystathionine + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens
pyridoxal 5'-phosphate 4 pyridoxal phosphate molecules per tetramer Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3
-
cyanide 37°C Homo sapiens
5.6
-
CO 37°C under anaerobic conditions Homo sapiens