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Literature summary for 4.2.1.22 extracted from

  • Walker, J.; Barrett, J.
    Biochemical characterization of the enzyme responsible for activated L-serine sulphydrase" activity in nematodes (1992), Exp. Parasitol., 74, 205-215.
    View publication on PubMed
Search for more literature for 4.2.1.22

Inhibitors

Inhibitors Comment Organism Structure
2,4-Dichlorophenol
-
 Haemonchus contortus
2,4-Dichlorophenol
-
 Nippostrongylus brasiliensis
alizarin
-
 Haemonchus contortus
alizarin
-
 Nippostrongylus brasiliensis
aminooxyacetic acid
-
 Haemonchus contortus
aminooxyacetic acid
-
 Nippostrongylus brasiliensis
bithionol
-
 Haemonchus contortus
bithionol
-
 Nippostrongylus brasiliensis
closantel
-
 Haemonchus contortus
closantel
-
 Nippostrongylus brasiliensis
Dichlorophene
-
 Haemonchus contortus
Dichlorophene
-
 Nippostrongylus brasiliensis
ellagic acid
-
 Haemonchus contortus
ellagic acid
-
 Nippostrongylus brasiliensis
Hexachlorophene
-
 Haemonchus contortus
Hexachlorophene
-
 Nippostrongylus brasiliensis
purpurogallin
-
 Haemonchus contortus
purpurogallin
-
 Nippostrongylus brasiliensis
quercetin
-
 Haemonchus contortus
quercetin
-
 Nippostrongylus brasiliensis
Rafoxanide
-
 Haemonchus contortus
Rafoxanide
-
 Nippostrongylus brasiliensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.21
-
 L-Cys
-
 Haemonchus contortus
5.58
-
 2-mercaptoethanol
-
 Haemonchus contortus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Haemonchus contortus 5829
-
cytosol
-
 Nippostrongylus brasiliensis 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Serine + homocysteine Haemonchus contortus
-
 ?
-
 ?
L-Serine + homocysteine Nippostrongylus brasiliensis
-
 ?
-
 ?
L-Serine + homocysteine Trichostrongylus colubriformis
-
 ?
-
 ?
L-Serine + homocysteine Steinernema bibionis
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Haemonchus contortus
-
-
-
Nippostrongylus brasiliensis
-
-
-
Steinernema bibionis
-
-
-
Trichostrongylus colubriformis
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-serine + L-homocysteine = L-cystathionine + H2O sequential bisubstrate mechanism in which no product release occurs until both substrates are bound to the enzyme to form a ternary complex Trichostrongylus colubriformis
a
L-serine + L-homocysteine = L-cystathionine + H2O sequential bisubstrate mechanism in which no product release occurs until both substrates are bound to the enzyme to form a ternary complex Steinernema bibionis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Cysteine + 1-butanethiol
-
 Haemonchus contortus ?
-
 ?
L-Cysteine + 1-butanethiol
-
 Nippostrongylus brasiliensis ?
-
 ?
L-Cysteine + 1-mercapto-2-propanol
-
 Haemonchus contortus HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
 ?
L-Cysteine + 1-mercapto-2-propanol
-
 Nippostrongylus brasiliensis HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
 ?
L-Cysteine + 1-mercapto-2-propanol
-
 Trichostrongylus colubriformis HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
 ?
L-Cysteine + 1-pentanethiol
-
 Haemonchus contortus ?
-
 ?
L-Cysteine + 1-pentanethiol
-
 Nippostrongylus brasiliensis ?
-
 ?
L-Cysteine + 2-mercaptoethanol
-
 Trichostrongylus colubriformis HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
 ?
L-Cysteine + 2-mercaptoethanol
-
 Steinernema bibionis HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
 ?
L-cysteine + 2-mercaptoethanol
-
 Haemonchus contortus S-hydroxyethyl-L-cysteine + H2S
-
 ?
L-Cysteine + cysteamine
-
 Haemonchus contortus ?
-
 ?
L-Cysteine + cysteamine
-
 Nippostrongylus brasiliensis ?
-
 ?
L-Cysteine + dithioerythritol
-
 Haemonchus contortus ?
-
 ?
L-Cysteine + dithioerythritol
-
 Nippostrongylus brasiliensis ?
-
 ?
L-Cysteine + dithiothreitol
-
 Haemonchus contortus ?
-
 ?
L-Cysteine + dithiothreitol
-
 Nippostrongylus brasiliensis ?
-
 ?
L-Cysteine + DL-homocysteine
-
 Haemonchus contortus Cystathionine + H2S
-
 ?
L-Cysteine + DL-homocysteine
-
 Nippostrongylus brasiliensis Cystathionine + H2S
-
 ?
L-Cysteine + DL-homocysteine
-
 Trichostrongylus colubriformis Cystathionine + H2S
-
 ?
L-Cysteine + monothioglycerol
-
 Haemonchus contortus ?
-
 ?
L-Cysteine + monothioglycerol
-
 Nippostrongylus brasiliensis ?
-
 ?
L-Cysteine + monothioglycerol
-
 Trichostrongylus colubriformis ?
-
 ?
L-Serine + homocysteine
-
 Haemonchus contortus Cystathionine + H2O
-
 ?
L-Serine + homocysteine
-
 Nippostrongylus brasiliensis Cystathionine + H2O
-
 ?
L-Serine + homocysteine
-
 Trichostrongylus colubriformis Cystathionine + H2O
-
 ?
L-Serine + homocysteine
-
 Steinernema bibionis Cystathionine + H2O
-
 ?
L-Serine + homocysteine
-
 Haemonchus contortus ?
-
 ?
L-Serine + homocysteine
-
 Nippostrongylus brasiliensis ?
-
 ?
L-Serine + homocysteine
-
 Trichostrongylus colubriformis ?
-
 ?
L-Serine + homocysteine
-
 Steinernema bibionis ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
 Haemonchus contortus
9
-
-
 Nippostrongylus brasiliensis

pH Range

pH Minimum pH Maximum Comment Organism
4.5 10.5
-
 Nippostrongylus brasiliensis
6.5 10.5
-
 Haemonchus contortus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate requirement Haemonchus contortus
pyridoxal 5'-phosphate requirement Nippostrongylus brasiliensis