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Literature summary for 4.2.1.20 extracted from

  • Bahar, I.; Jernigan, R.L.
    Cooperative fluctuations and subunit communication in tryptophan synthase (1999), Biochemistry, 38, 3478-3490.
    View publication on PubMed
Search for more literature for 4.2.1.20

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(indol-3-yl)glycerol 3-phosphate + L-serine Salmonella enterica subsp. enterica serovar Typhimurium alpha-subunit of the bienzyme complex, alpha-reaction L-tryptophan + D-glyceraldehyde 3-phosphate
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 ?
L-serine + indole Salmonella enterica subsp. enterica serovar Typhimurium beta-subunit of the bienzyme complex, beta-reaction tryptophan + H2O
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 ?
additional information Salmonella enterica subsp. enterica serovar Typhimurium last 2 steps of the tryptophan biosynthesis ?
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 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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-
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Reaction

Reaction Comment Organism Reaction ID
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O also catalyses the conversion of serine and indole into tryptophan and water, and of indoleglycerol phosphate into indole and glyceraldehyde phosphate (the latter reaction was listed formerly as EC 4.2.1.8), mechanism, ligand binding, unique ligand-mediated long-range cooperativity for substrate channeling, allosteric control, coordination of metabolic cycles Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(indol-3-yl)glycerol 3-phosphate alpha-subunit of the bienzyme complex, alpha-reaction Salmonella enterica subsp. enterica serovar Typhimurium D-glyceraldehyde 3-phosphate + indole
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 ?
1-(indol-3-yl)glycerol 3-phosphate + L-serine alpha-subunit of the bienzyme complex, alpha-reaction Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + D-glyceraldehyde 3-phosphate
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 ?
L-serine + indole beta-subunit of the bienzyme complex, beta-reaction Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + H2O
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 ?
L-serine + indole beta-subunit of the bienzyme complex, beta-reaction Salmonella enterica subsp. enterica serovar Typhimurium tryptophan + H2O
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 ?
additional information the intermediate product indole is transferred from the alpha- to the beta-site through a 25 A long hydrophobic tunnel Salmonella enterica subsp. enterica serovar Typhimurium ?
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 ?
additional information last 2 steps of the tryptophan biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium ?
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 ?

Subunits

Subunits Comment Organism
More crystal structure analysis, structure-function relationship, overview Salmonella enterica subsp. enterica serovar Typhimurium
tetramer alpha2beta2 complex Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

Synonyms Comment Organism
TRPS
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 Salmonella enterica subsp. enterica serovar Typhimurium