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Literature summary for 4.2.1.113 extracted from

  • Pulaganti, M.; Banaganapalli, B.; Mulakayala, C.; Chitta, S.K.; C M, A.
    Molecular modeling and docking studies of O-succinylbenzoate synthase of M. tuberculosis - a potential target for antituberculosis drug design (2014), Appl. Biochem. Biotechnol., 172, 1407-1432.
    View publication on PubMed
Search for more literature for 4.2.1.113

Application

Application Comment Organism
drug development the enzyme plays a major role in menaquinone biosynthesis and is one of the major potential drug targets for development of antibiotics Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
gene menC, phylogenetic analysis Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
additional information docking of potential inhibitors, inhibitor development via competitive binding of the substrate, overview. Design of a substrate-based analogue, evaluation of auxiliary molecule interaction energies through molecular docking and molecular dynamic simulation studies Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis
-
 2-succinylbenzoate + H2O
-
 ?
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis H37Rv
-
 2-succinylbenzoate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
 gene menC
-
Mycobacterium tuberculosis H37Rv
-
 gene menC
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis 2-succinylbenzoate + H2O
-
 ?
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis H37Rv 2-succinylbenzoate + H2O
-
 ?

Subunits

Subunits Comment Organism
More three-dimensional structure modeling taking crystal structure of the enzyme from Thermobifida fusca YX (PDB ID 2OPJ) as the template, overview Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
OSBS
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism the enzyme is important in the menaquinone biosynthesis Mycobacterium tuberculosis
additional information Lys108, Asn140, Asp138, Lys110, Glu189, Ser236, Asp188, Arg27, Tyr52, and Ser237 are highly conserved and may play a vital role as active residues Mycobacterium tuberculosis