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Literature summary for 4.2.1.11 extracted from

  • Nogueira, S.V.; Fonseca, F.L.; Rodrigues, M.L.; Mundodi, V.; Abi-Chacra, E.A.; Winters, M.S.; Alderete, J.F.; de Almeida Soares, C.M.
    Paracoccidioides brasiliensis enolase is a surface protein that binds plasminogen and mediates interaction of yeast forms with host cells (2010), Infect. Immun., 78, 4040-4050.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged enolase in Escherichia coli Paracoccidioides brasiliensis

Protein Variants

Protein Variants Comment Organism
additional information immobilization of purified recombinant enolase Paracoccidioides brasiliensis

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Paracoccidioides brasiliensis 9986
-
cytosol
-
 Paracoccidioides brasiliensis 5829
-
extracellular
-
 Paracoccidioides brasiliensis
-
-

Organism

Organism UniProt Comment Textmining
Paracoccidioides brasiliensis A5JQI1
-
-
Paracoccidioides brasiliensis ATCC MYA-826 A5JQI1
-
-

Synonyms

Synonyms Comment Organism
enolase
-
 Paracoccidioides brasiliensis

General Information

General Information Comment Organism
physiological function enolase acts as a fibronectin binding protein in Paracoccidioides brasiliensis. Association between recombinant PbEno and plasminogen is lysine-dependent and is dependent on cell surface localization of PbENo, since purified rPbEno, in its soluble form, inhibits plasminogen binding to fixed cells, interaction analysis, overview. Exposure of epithelial cells and phagocytes to enolase is associated with an increased expression of surface sites of adhesion. In fact, the association of Paracoccidioides brasiliensis with epithelial cells and phagocytes is increased in the presence of rPbEno Paracoccidioides brasiliensis