Literature summary for 4.2.1.10 extracted from

Gourley, D.G.; Shrive, A.K.; Polikarpov, I.; Krell, T.; Coggins, J.R.; Hawkins, A.R.; Isaacs, N.W.; Sawyer, L.
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction (1999), Nat. Struct. Biol., 6, 521-525.

Search for more literature for 4.2.1.10

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Salmonella enterica subsp. enterica serovar Typhi
-	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3-dehydroquinate	Helicobacter pylori	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	-	dehydroquinase type II	-
Mycobacterium tuberculosis	P9WPX7	dehydroquinase type II	-
Mycobacterium tuberculosis H37Rv	P9WPX7	dehydroquinase type II	-
Salmonella enterica subsp. enterica serovar Typhi	-	-	-
Salmonella enterica subsp. enterica serovar Typhi	-	dehydroquinase type I	-
Streptomyces coelicolor	-	dehydroquinase type II	-

Reaction

Reaction	Comment	Organism	Reaction ID
3-dehydroquinate = 3-dehydroshikimate + H2O	type I dehydroquinase catalyzes cis-dehydration of 3-dehydroquinate via a covalent imine intermediate	Salmonella enterica subsp. enterica serovar Typhi	a
3-dehydroquinate = 3-dehydroshikimate + H2O	type II dehydroquinase catalyzes a trans-dehydration via an enolate intermediate	Streptomyces coelicolor	a
3-dehydroquinate = 3-dehydroshikimate + H2O	type II dehydroquinase catalyzes a trans-dehydration via an enolate intermediate	Helicobacter pylori	a
3-dehydroquinate = 3-dehydroshikimate + H2O	type II dehydroquinase catalyzes a trans-dehydration via an enolate intermediate	Mycobacterium tuberculosis	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-dehydroquinate	-	Helicobacter pylori	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)