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Literature summary for 4.1.99.3 extracted from

  • Thoma, F.
    Light and dark in chromatin repair: repair of UV-induced DNA lesions by photolyase and nucleotide excision repair (1999), EMBO J., 18, 6585-6598.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.99.3

Activating Compound

Activating Compound Comment Organism Structure
FAD enzyme contains FAD as catalytic cofactor and a second chromophore as a light harvesting antenna Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
RNA polymerase II transcription by RNAPII and RNAPIII slows down the repair by photolyase on the transcribed strands Saccharomyces cerevisiae
RNA polymerase III transcription by RNAPII and RNAPIII slows down the repair by photolyase on the transcribed strands Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli major pathway to remove UV-induced DNA lesions from the genome ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
no activity in mammalia
-
-
-
Saccharomyces cerevisiae
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclobutadipyrimidine in DNA
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 Saccharomyces cerevisiae 2 pyrimidine residues in DNA
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 ?
cyclobutadipyrimidine in DNA upon binding of DNA, the enzyme flips the pyrimidine dimer out of the duplex into a hole that contains the catalytic cofactor. The cyclobutane ring is then split by a light-initiated electron transfer reaction Escherichia coli 2 pyrimidine residues in DNA
-
 ?
cyclobutadipyrimidine in nucleosome DNA folding of DNA in nucleosomes efficiently protects DNA from being repaired Escherichia coli 2 pyrimidine residues in nucleosome DNA
-
 ?
additional information major pathway to remove UV-induced DNA lesions from the genome Escherichia coli ?
-
 ?