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Literature summary for 4.1.99.17 extracted from

  • Martinez-Gomez, N.C.; Downs, D.M.
    ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis (2008), Biochemistry, 47, 9054-9056.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
4Fe-4S cluster ThiC carries an oxygen labile [Fe-S] cluster essential for activity Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium Q9L9I7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine
-
 Salmonella enterica subsp. enterica serovar Typhimurium 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
4Fe-4S-center ThiC carries an oxygen labile [Fe-S] cluster essential for activity Salmonella enterica subsp. enterica serovar Typhimurium

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of thiamine diphosphate Salmonella enterica subsp. enterica serovar Typhimurium