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Literature summary for 4.1.3.39 extracted from

  • Smith, N.E.; Vrielink, A.; Attwood, P.V.; Corry, B.
    Binding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study (2014), Biophys. J., 106, 1681-1690.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.3.39

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxy-2-oxovalerate Pseudomonas sp. physiological substrate acetaldehyde + pyruvate
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 ?
4-hydroxy-2-oxovalerate Pseudomonas sp. CF 600 physiological substrate acetaldehyde + pyruvate
-
 ?
additional information Pseudomonas sp. DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview ?
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 ?
additional information Pseudomonas sp. CF 600 DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas sp. P51016 dmpG
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Pseudomonas sp. CF 600 P51016 dmpG
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxy-2-oxo-4-benzylbutanoate
-
 Pseudomonas sp. benzaldehyde + pyruvate
-
 ?
4-hydroxy-2-oxo-isoheptanoate
-
 Pseudomonas sp. isobutyraldehyde + pyruvate
-
 ?
4-hydroxy-2-oxoheptanoate
-
 Pseudomonas sp. butyraldehyde + pyruvate
-
 ?
4-hydroxy-2-oxohexanoate
-
 Pseudomonas sp. propionaldehyde + pyruvate
-
 ?
4-hydroxy-2-oxohexanoate
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 Pseudomonas sp. CF 600 propionaldehyde + pyruvate
-
 ?
4-hydroxy-2-oxovalerate physiological substrate Pseudomonas sp. acetaldehyde + pyruvate
-
 ?
4-hydroxy-2-oxovalerate physiological substrate, the R and the S forms are both accommodated within the DmpG active site Pseudomonas sp. acetaldehyde + pyruvate
-
 ?
4-hydroxy-2-oxovalerate physiological substrate Pseudomonas sp. CF 600 acetaldehyde + pyruvate
-
 ?
4-hydroxy-2-oxovalerate physiological substrate, the R and the S forms are both accommodated within the DmpG active site Pseudomonas sp. CF 600 acetaldehyde + pyruvate
-
 ?
additional information DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview Pseudomonas sp. ?
-
 ?
additional information substrate specificity, substrate docking into the active site and modeling, binding structures, overview Pseudomonas sp. ?
-
 ?
additional information DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview Pseudomonas sp. CF 600 ?
-
 ?
additional information substrate specificity, substrate docking into the active site and modeling, binding structures, overview Pseudomonas sp. CF 600 ?
-
 ?

Subunits

Subunits Comment Organism
More DmpFG is a microbial enzyme comprised of two subunits DmpG and DmpF Pseudomonas sp.

Synonyms

Synonyms Comment Organism
4-hydroxy-2-ketovalerate aldolase-aldehyde dehydrogenase (acylation)
-
 Pseudomonas sp.
DmpFG
-
 Pseudomonas sp.

General Information

General Information Comment Organism
metabolism DmpFG catalyzes the final two steps of the meta-cleavage pathway of catechol and its methylated substituents. This pathway breaks down toxic waste products such as naphthalenes, salicylates, and benzoates to harmless metabolites Pseudomonas sp.