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Literature summary for 4.1.3.3 extracted from

  • Xiao, S.; Li, R.; Diao, H.; Zhao, F.; Ye, X.
    Progesterone receptor-mediated regulation of N-acetylneuraminate pyruvate lyase (NPL) in mouse uterine luminal epithelium and nonessential role of NPL in uterine function (2013), PLoS ONE, 8, e65607.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.3.3

Cloned(Commentary)

Cloned (Comment) Organism
gene npl, realtime RT-PCR enzyme expression analysis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus B6/129S5-NplGt(IRESBetageo)332Lex/Mmucd
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-
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Source Tissue

Source Tissue Comment Organism Textmining
uterus progesterone-mediated dynamic expression of the enzyme in the periimplantation uterus, Npl expression increases 56fold from gestation day 0.5 to day 2.5. In ovariectomized mouse uterus Mus musculus
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Synonyms

Synonyms Comment Organism
N-acetylneuraminate pyruvate lyase
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 Mus musculus
NPL
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus gene npl is downregulated by 17beta-estradiol down
Mus musculus gene npl is significantly upregulated by progesterone. Progesterone receptor antagonist RU486 blocks the upregulation of Npl in both preimplantation uterus and progesterone-treated ovariectomized uterus up

General Information

General Information Comment Organism
physiological function the enzyme regulates the cellular concentrations of sialic acid and preventing the recycling of sialic acid for further sialiation with glycoconjuates in the Golgi compartment. The enzyme plays a dispensable role in uterine function and embryo development Mus musculus