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Literature summary for 4.1.3.3 extracted from

  • Schauer, R.; Sommer, U.; Kruger, D.; van Unen, H.; Traving, C.
    The terminal enzymes of sialic acid metabolism: acylneuraminate pyruvate-lyases (1999), Biosci. Rep., 19, 373-383.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-chloromercuribenzoate
-
Clostridium perfringens
4-chloromercuribenzoate
-
Sus scrofa
5-Diazonium-1-H-tetrazole
-
Clostridium perfringens
5-Diazonium-1-H-tetrazole
-
Sus scrofa
Bromopyruvate
-
Clostridium perfringens
Bromopyruvate
-
Sus scrofa
cyanide
-
Clostridium perfringens
cyanide
-
Sus scrofa
diethylpyrocarbonate
-
Sus scrofa
diisopropylfluorophosphate
-
Clostridium perfringens
diisopropylfluorophosphate
-
Sus scrofa
N-bromosuccinimide
-
Sus scrofa
N-ethylmaleimide
-
Clostridium perfringens
N-ethylmaleimide
-
Sus scrofa
phenylmethylsulfonyl fluoride
-
Sus scrofa
pyruvate
-
Clostridium perfringens
pyruvate
-
Sus scrofa
Rose bengal
-
Clostridium perfringens
Rose bengal
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5 3.7 N-acetylneuraminic acid
-
Sus scrofa
1.9 3.9 N-acetylneuraminic acid
-
Clostridium perfringens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
2 * 33000, SDS-PAGE Clostridium perfringens

Organism

Organism UniProt Comment Textmining
Clostridium perfringens
-
-
-
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
aceneuramate = N-acetyl-D-mannosamine + pyruvate mechanism Sus scrofa
aceneuramate = N-acetyl-D-mannosamine + pyruvate mechanism Clostridium perfringens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.42 1.5
-
Sus scrofa
10
-
-
Clostridium perfringens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-N-acetyl-4-O-acetylneuraminic acid 22% the activity with N-acetylneuraminic acid Clostridium perfringens ?
-
?
5-N-acetyl-9-O-acetylneuraminic acid 32.45% the activity with N-acetylneuraminic acid Sus scrofa ?
-
?
N-Acetylneuraminic acid
-
Sus scrofa N-Acetyl-D-mannosamine + pyruvate
-
r
N-Acetylneuraminic acid
-
Clostridium perfringens N-Acetyl-D-mannosamine + pyruvate
-
r
N-Formylneuraminic acid
-
Clostridium perfringens ?
-
?
N-Glycolylneuraminic acid
-
Sus scrofa ?
-
?
N-Glycolylneuraminic acid
-
Clostridium perfringens ?
-
?
N-Monochloracetylneuraminic acid
-
Clostridium perfringens ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 33000, SDS-PAGE Clostridium perfringens
More enzyme is a monomer or a tetramer Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
65 70
-
Clostridium perfringens
70 80
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
Clostridium perfringens
7.2 8
-
Sus scrofa

pI Value

Organism Comment pI Value Maximum pI Value
Clostridium perfringens
-
4.8 4.7
Sus scrofa
-
-
5.5