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Literature summary for 4.1.3.3 extracted from

  • Comb, D.G.; Roseman, S.
    The sialic acids. I. Structure and enzymatic synthesis of N-acetylneuraminic acid (1960), J. Biol. Chem., 235, 2529-2537.
    View publication on PubMed
Search for more literature for 4.1.3.3

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.3
-
 N-acetylneuraminic acid
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-Acetylmannosamine + pyruvate Escherichia coli
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10
-
 N-acetylneuraminic acid Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-Acetyl-D-mannosamine + pyruvate
-
 Escherichia coli N-Acetylneuraminic acid
-
 r
N-Acetyl-D-mannosamine + pyruvate
-
 Rattus norvegicus N-Acetylneuraminic acid
-
 r
N-Acetylmannosamine + pyruvate
-
 Escherichia coli ?
-
 ?
N-Acetylneuraminic acid
-
 Escherichia coli N-Acetyl-D-mannosamine + pyruvate
-
 r
N-Acetylneuraminic acid
-
 Rattus norvegicus N-Acetyl-D-mannosamine + pyruvate
-
 r
N-Glycolylneuraminic acid
-
 Escherichia coli ?
-
 ?