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Literature summary for 4.1.1.71 extracted from

  • Tian, J.; Bryk, R.; Itoh, M.; Suematsu, M.; Nathan, C.
    Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase (2005), Proc. Natl. Acad. Sci. USA, 102, 10670-10675.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.71

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.48
-
 2-oxoglutarate 22°C, pH 7.0 Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ strictly required, Km-value 0.196 mM Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycobacterium tuberculosis enzyme and GabD1 or GabD2 form an alternative pathway from 2-oxoglutarate to succinate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate
-
 Mycobacterium tuberculosis succinate semialdehyde + CO2
-
 ?
additional information enzyme and GabD1 or GabD2 form an alternative pathway from 2-oxoglutarate to succinate Mycobacterium tuberculosis ?
-
 ?
additional information no substrate: pyruvate Mycobacterium tuberculosis ?
-
 ?

Synonyms

Synonyms Comment Organism
Kgd
-
 Mycobacterium tuberculosis
Rv1248c
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
additional information no cofactor: coenzyme A, NAD+, NADP+ Mycobacterium tuberculosis
thiamine diphosphate Km-value 0.019 mM Mycobacterium tuberculosis