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Literature summary for 4.1.1.65 extracted from
- Phosphatidylserine decarboxylases: pyruvoyl-dependent enzymes from bacteria to mammals (1997), Methods Enzymol., 280, 81-88.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| pyruvate | the pyruvoyl residue is covalently bound to the amino terminus of one of the two nonidentical subunits | Escherichia coli |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44172 | - |
1 * 3545, alpha, + 1 * 44172, beta | Cricetulus griseus |
| 52367 | - |
1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1 | Saccharomyces cerevisiae |
| 118868 | - |
1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2 | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | the enzyme is synthesized as a single subunit proenzyme form, pi subunit, 35579 Da, which undergoes posttranslational processing in which an internal Ser residue becomes the covalently bound prosthetic group of one of the two resulting subunits | Escherichia coli |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| phosphatidyl-L-serine = phosphatidylethanolamine + CO2 | decarboxylation via Schiff base formation between a covalently bound pyruvoyl prosthetic group and the amine of serine | Escherichia coli |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary | - |
Cricetulus griseus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Phosphatidyl-L-serine | - |
Cricetulus griseus | Phosphatidylethanolamine + CO2 | - |
? | |
| Phosphatidyl-L-serine | - |
Escherichia coli | Phosphatidylethanolamine + CO2 | - |
? | |
| Phosphatidyl-L-serine | - |
Homo sapiens | Phosphatidylethanolamine + CO2 | - |
? | |
| Phosphatidyl-L-serine | - |
Saccharomyces cerevisiae | Phosphatidylethanolamine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Escherichia coli |
| dimer | 1 * 1090, alpha, + 1 * 118868, beta, enzyme form PSD2 | Saccharomyces cerevisiae |
| dimer | 1 * 3545, alpha, + 1 * 44172, beta | Cricetulus griseus |
| dimer | 1 * 4192, alpha, + 1 * 52367, beta, enzyme form PSD1 | Saccharomyces cerevisiae |
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