Literature summary for 4.1.1.48 extracted from

Tang, X.; Ezaki, S.; Fujiwara, S.; Takagi, M.; Atomi, H.; Imanaka, T.
The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA (1999), Mol. Gen. Genet., 262, 815-821.

Search for more literature for 4.1.1.48

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Thermococcus kodakarensis

Organism

Organism	UniProt	Comment	Textmining
Thermococcus kodakarensis	Q9YGB5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	Thermococcus kodakarensis	1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
indole-3-glycerolphosphate synthase	-	Thermococcus kodakarensis
InGPS	-	Thermococcus kodakarensis
Pk-trpC	-	Thermococcus kodakarensis

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
85	-	-	Thermococcus kodakarensis

Temperature Range [°C]

Temperature Minimum [°C]	Temperature Maximum [°C]	Comment	Organism
60	95	60°C: about 50% of maximal activity, 95°C: about 45% of maximal activity	Thermococcus kodakarensis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.5	-	-	Thermococcus kodakarensis

Expression

Organism	Comment	Expression
Thermococcus kodakarensis	a significant increase in trp mRNA level is observed in cells grown in medium depleted of L-tryptophan, compared to cells grown in medium supplemented with L-tryptophan, indicating that expression of the gene cluster is regulated at the transcriptional level	up

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Release 2023.1 (January 2023)