Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharolobus solfataricus | Q06121 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O | molecular dynamics simulation study of the enzyme-substrate complex at room temperature and at 110°C. Relative specific activity increases 4200fold up to 110°C. Active site residues K53 and K110 control the binding of substrate in the favorable orientation for the general acid-catalyzed intramolecular ring formation reaction | Saccharolobus solfataricus |