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Literature summary for 4.1.1.48 extracted from

  • Mazumder-Shivakumar, D.; Kahn, K.; Bruice, T.C.
    Computational study of the ground state of thermophilic indole glycerol phosphate synthase: structural alterations at the active site with temperature (2004), J. Am. Chem. Soc., 126, 5936-5937.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q06121
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Reaction

Reaction Comment Organism Reaction ID
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O molecular dynamics simulation study of the enzyme-substrate complex at room temperature and at 110°C. Relative specific activity increases 4200fold up to 110°C. Active site residues K53 and K110 control the binding of substrate in the favorable orientation for the general acid-catalyzed intramolecular ring formation reaction Saccharolobus solfataricus