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Literature summary for 4.1.1.48 extracted from
- Indole-3-glycerol-phosphate synthase from Sulfolobus solfataricus as a model for studying thermostable TIM-barrel enzymes (1994), Biochim. Biophys. Acta, 1208, 310-315.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharolobus solfataricus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0026 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate | at 60°C | Saccharolobus solfataricus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21000 | - |
gel filtration | Saccharolobus solfataricus |
| 27000 | - |
1 * 27000, SDS-PAGE | Saccharolobus solfataricus |
| 28566 | - |
1 * 28566, calculation from nucleotide sequence | Saccharolobus solfataricus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Saccharolobus solfataricus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate | - |
Escherichia coli | 1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O | - |
? | |
| 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate | - |
Saccharolobus solfataricus | 1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Escherichia coli |
| monomer | 1 * 27000, SDS-PAGE | Saccharolobus solfataricus |
| monomer | 1 * 28566, calculation from nucleotide sequence | Saccharolobus solfataricus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 84 | - |
- |
Saccharolobus solfataricus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 75 | - |
90 min, 50% loss of activity | Saccharolobus solfataricus |
| 80 | - |
20 min, 50% loss of activity | Saccharolobus solfataricus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.15 | - |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate | at 60°C | Saccharolobus solfataricus | |
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Release 2023.1 (January 2023)
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