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Literature summary for 4.1.1.37 extracted from

  • Ito, E.; Yue, S.; Moriyama, E.H.; Hui, A.B.; Kim, I.; Shi, W.; Alajez, N.M.; Bhogal, N.; Li, G.; Datti, A.; Schimmer, A.D.; Wilson, B.C.; Liu, P.P.; Durocher, D.; Neel, B.G.; OSullivan, B.; Cummings, B.; Bristow, R.; Wrana, J.; Liu, F.F.
    Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer (2011), Sci. Transl. Med., 3, 67ra7.
    View publication on PubMed
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Application

Application Comment Organism
medicine uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Synonyms

Synonyms Comment Organism
UroD
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens UROD is significantly overexpressed in head and neck cancer patient biopsies up

General Information

General Information Comment Organism
malfunction UROD knockdown plus radiation induces caspase-mediated apoptosis and cell cycle arrest in head and neck cancer cells in vitro and suppresses the in vivo tumor-forming capacity of head and neck cancer cells, as well as delays the growth of established tumor xenografts in mice Homo sapiens
metabolism UROD is a key regulator of heme biosynthesis Homo sapiens