Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Reducing agents | required | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithiobis(2-nitrobenzoate) | - |
Homo sapiens | |
Butanedione | - |
Homo sapiens | |
Cu2+ | - |
Homo sapiens | |
diethyldicarbonate | reversed by hydroxylamine | Homo sapiens | |
Hg2+ | - |
Homo sapiens | |
NEM | prior incubation with 5-COOH-porphyrinogen III prevents inactivation | Homo sapiens | |
PCMB | - |
Homo sapiens | |
Phenylglyoxal | - |
Homo sapiens | |
Pt2+ | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00005 | - |
5-COOH-porphyrinogen III | - |
Homo sapiens | |
0.00007 | - |
5-COOH-porphyrinogen I | - |
Homo sapiens | |
0.00035 | - |
uroporphyrinogen III | - |
Homo sapiens | |
0.0008 | - |
Uroporphyrinogen I | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40831 | - |
x * 40831, calculation from nucleotide sequence | Homo sapiens |
58000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme of the heme biosynthetic pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oxidation Stability | Organism |
---|---|
rapid inactivation by uroporphyrin-catalyzed photooxidation | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-COOH-porphyrinogen I | - |
Homo sapiens | Coproporphyrinogen I + CO2 | - |
? | |
5-COOH-porphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + CO2 | - |
? | |
additional information | enzyme of the heme biosynthetic pathway | Homo sapiens | ? | - |
? | |
uroporphyrinogen I | - |
Homo sapiens | coproporphyrinogen I + 4 CO2 | - |
? | |
Uroporphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + 4 CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40831, calculation from nucleotide sequence | Homo sapiens |
? | x * 39500-41000, SDS-PAGE | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.4 | - |
- |
Homo sapiens |
6.2 | - |
- |
Homo sapiens |
6.8 | - |
with uroporphyrinogen III or 5-COOH-porphyrinogen III as substrate | Homo sapiens |