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Literature summary for 4.1.1.36 extracted from

  • Kumar, P.; Chhibber, M.; Surolia, A.
    How pantothenol intervenes in coenzyme-A biosynthesis of Mycobacterium tuberculosis (2007), Biochem. Biophys. Res. Commun., 361, 903-909.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) cells Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
4'-phosphopantothenol
-
Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA metal-affinity column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
Mycobacterium tuberculosis pantotheine 4'-phosphate + CO2
-
?

Synonyms

Synonyms Comment Organism
4'-phosphopantothenoylcysteine decarboxylase
-
Mycobacterium tuberculosis
CoaBC
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
flavin
-
Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.063
-
in 50 mM Tris, 0.2 mM cysteine, 0.2 mM CTP, 0.2 mM dithiothreitol, 0.2 mM MgCl2, at 37°C Mycobacterium tuberculosis 4'-phosphopantothenol