Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4'-phospho-N-(1-mercaptomethyl-cyclopropyl)-pantothenamide | i.e. PPanDELTASH, mechanism-based inhibitor, alkylating C173 residue of enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.118 | - |
(R)-4'-phospho-N-pantothenoylcysteine | pH 7.6, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
N-[(R)-4'-phosphopantothenoyl]-L-cysteine = pantotheine 4'-phosphate + CO2 | C173 serves as an active site acid in the protonation of the enethiolate intermediate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-4'-phospho-N-pantothenoylcysteine | - |
Homo sapiens | pantotheine 4'-phosphate + CO2 | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.9 | - |
(R)-4'-phospho-N-pantothenoylcysteine | pH 7.6, 37°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2.58 | - |
4'-phospho-N-(1-mercaptomethyl-cyclopropyl)-pantothenamide | pH 7.6, 37°C | Homo sapiens |