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Literature summary for 4.1.1.31 extracted from

  • Storm, J.; Sethia, S.; Blackburn, G.J.; Chokkathukalam, A.; Watson, D.G.; Breitling, R.; Coombs, G.H.; Mueller, S.
    Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism (2014), PLoS Pathog., 10, e1003876.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3,3-dichloro-2-(dihydroxyphosphinoylmethyl) propenoate micromolar inhibitor Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoenolpyruvate + HCO3- Plasmodium falciparum
-
phosphate + oxaloacetate
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + HCO3-
-
Plasmodium falciparum phosphate + oxaloacetate
-
?

Synonyms

Synonyms Comment Organism
PEPC
-
Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Plasmodium falciparum

General Information

General Information Comment Organism
malfunction an enzyme-deficient mutant shows severe growth defect in vitro Plasmodium falciparum
metabolism the enzyme has a key role in carbon metabolism by fixing CO2 Plasmodium falciparum
physiological function the phosphoenolpyruvate carboxylase gene is important for intra-erythrocytic survival of Plasmodium falciparum Plasmodium falciparum