Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Plasmodium falciparum |
Crystallization (Comment) | Organism |
---|---|
crystal structure in complex with inhibitor (5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate. Compared to cytosin, the pyrimidine portion exhibits changes in the atomic arrangement. The oxygen atom migrates from N3 to N4 or the C5 position of the cytosine ring. These rearranged nucleotides are each bound to the enzyme in a 2?-endo,syn conformation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate | i.e. CMP-N3-oxide | Homo sapiens | |
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate | i.e. CMP-N3-oxide | Plasmodium falciparum | |
CMP | weak inhibitor | Homo sapiens | |
CMP | weak inhibitor | Plasmodium falciparum | |
UMP | - |
Homo sapiens | |
UMP | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11172 | - |
- |
Plasmodium falciparum | Q8IJH3 | isolate 3D7 | - |
Synonyms | Comment | Organism |
---|---|---|
ODCase | - |
Homo sapiens |
ODCase | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate | pH 7.5, 22°C | Plasmodium falciparum | |
0.028 | - |
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate | pH 7.5, 22°C | Homo sapiens | |
0.21 | - |
UMP | pH 7.5, 22°C | Plasmodium falciparum | |
0.22 | - |
UMP | pH 7.5, 22°C | Homo sapiens | |
1.4 | - |
CMP | pH 7.5, 22°C | Homo sapiens |