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Literature summary for 4.1.1.23 extracted from

  • Lewis, M.; Meza-Avina, M.E.; Wei, L.; Crandall, I.E.; Bello, A.M.; Poduch, E.; Liu, Y.; Paige, C.J.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
    Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase (2011), J. Med. Chem., 54, 2891-2901.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.23

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxy-2'-fluoro-6-iodo-beta-D-uridine 5'-O-monophosphate
-
 Homo sapiens
2'-deoxy-2'-fluoro-6-iodo-beta-D-uridine 5'-O-monophosphate
-
 Methanothermobacter thermautotrophicus
2'-deoxy-2'-fluoro-6-iodo-UMP
-
 Homo sapiens
2'-deoxy-2'-fluoro-6-iodo-UMP
-
 Methanothermobacter thermautotrophicus
2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-cytosine
-
 Homo sapiens
2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-cytosine
-
 Methanothermobacter thermautotrophicus
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Homo sapiens
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Methanothermobacter thermautotrophicus
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate poor inhibitor Homo sapiens
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate poor inhibitor Methanothermobacter thermautotrophicus
6-amino-5-fluorouridine competitive inhibition at submicromolar concentrations Homo sapiens
6-amino-5-fluorouridine competitive inhibition at submicromolar concentrations Methanothermobacter thermautotrophicus
6-azauridine potent inhibitor Homo sapiens
6-azauridine potent inhibitor Methanothermobacter thermautotrophicus
6-azido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Homo sapiens
6-azido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Methanothermobacter thermautotrophicus
6-azido-5-fluorouridine irreversible inhibitor Homo sapiens
6-azido-5-fluorouridine irreversible inhibitor Methanothermobacter thermautotrophicus
6-azido-UMP
-
 Homo sapiens
6-azido-UMP
-
 Methanothermobacter thermautotrophicus
6-carbamoyl-UMP
-
 Methanothermobacter thermautotrophicus
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate reversible inhibitor Homo sapiens
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate reversible inhibitor Methanothermobacter thermautotrophicus
6-cyanouridine
-
 Homo sapiens
6-cyanouridine
-
 Methanothermobacter thermautotrophicus
6-hydroxyuridine potent inhibitor Homo sapiens
6-hydroxyuridine potent inhibitor Methanothermobacter thermautotrophicus
6-iodouridine
-
 Homo sapiens
6-iodouridine
-
 Methanothermobacter thermautotrophicus
6-thiocarboxamidouridine potent inhibitor Homo sapiens
6-thiocarboxamidouridine potent inhibitor Methanothermobacter thermautotrophicus
clevudine
-
 Homo sapiens
clevudine
-
 Methanothermobacter thermautotrophicus
gemcitabine
-
 Homo sapiens
gemcitabine
-
 Methanothermobacter thermautotrophicus
nifedipine competitive inhibitor Homo sapiens
nifedipine competitive inhibitor Methanothermobacter thermautotrophicus
nimodipine competitive inhibitor Homo sapiens
nimodipine competitive inhibitor Methanothermobacter thermautotrophicus
pyrazofurin potent inhibitor Homo sapiens
pyrazofurin potent inhibitor Methanothermobacter thermautotrophicus
Xanthosine potent inhibitor Homo sapiens
Xanthosine potent inhibitor Methanothermobacter thermautotrophicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Methanothermobacter thermautotrophicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Orotidine 5'-phosphate
-
 Homo sapiens UMP + CO2
-
 ?
Orotidine 5'-phosphate
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?
orotidine 5'-phosphate + H+
-
 Homo sapiens UMP + CO2
-
 ?
orotidine 5'-phosphate + H+
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODCase
-
 Homo sapiens
ODCase
-
 Methanothermobacter thermautotrophicus
OMPDCase
-
 Homo sapiens
OMPDCase
-
 Methanothermobacter thermautotrophicus
Orotidine 5'-monophosphate decarboxylase
-
 Homo sapiens
Orotidine 5'-monophosphate decarboxylase
-
 Methanothermobacter thermautotrophicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00132
-
 6-carbamoyl-UMP in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
0.0286
-
 6-cyanouridine in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
0.037
-
 6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
0.204
-
 6-cyanouridine in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens
0.36
-
 5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
0.759
-
 5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens
2
-
 6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate Ki above 2 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens
3.322
-
 6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
4
-
 6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate Ki above 4 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens