Cloned (Comment) | Organism |
---|---|
- |
Staphylococcus aureus |
- |
Homo sapiens |
- |
Saccharomyces cerevisiae |
- |
Methanothermobacter thermautotrophicus |
- |
Helicobacter pylori |
- |
Plasmodium falciparum |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with 4 and 10) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Saccharomyces cerevisiae |
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Staphylococcus aureus |
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Homo sapiens |
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Methanothermobacter thermautotrophicus |
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Helicobacter pylori |
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-cyano-UMP | poor inhibition | Helicobacter pylori | |
5-cyano-UMP | poor inhibition | Homo sapiens | |
5-cyano-UMP | poor inhibition | Methanothermobacter thermautotrophicus | |
5-cyano-UMP | poor inhibition | Plasmodium falciparum | |
5-cyano-UMP | poor inhibition | Saccharomyces cerevisiae | |
5-cyano-UMP | poor inhibition | Staphylococcus aureus | |
barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Helicobacter pylori | |
barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Homo sapiens | |
barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Methanothermobacter thermautotrophicus | |
barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Plasmodium falciparum | |
barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Saccharomyces cerevisiae | |
barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Staphylococcus aureus | |
nifedipine | competitive inhibition | Helicobacter pylori | |
nifedipine | competitive inhibition | Homo sapiens | |
nifedipine | competitive inhibition | Methanothermobacter thermautotrophicus | |
nifedipine | competitive inhibition | Plasmodium falciparum | |
nifedipine | competitive inhibition | Saccharomyces cerevisiae | |
nifedipine | competitive inhibition | Staphylococcus aureus | |
nimodipine | competitive inhibition | Helicobacter pylori | |
nimodipine | competitive inhibition | Homo sapiens | |
nimodipine | competitive inhibition | Methanothermobacter thermautotrophicus | |
nimodipine | competitive inhibition | Plasmodium falciparum | |
nimodipine | competitive inhibition | Saccharomyces cerevisiae | |
nimodipine | competitive inhibition | Staphylococcus aureus | |
pyrazofurin | also known as pyrazomycin, potent inhibitor | Helicobacter pylori | |
pyrazofurin | also known as pyrazomycin, potent inhibitor | Homo sapiens | |
pyrazofurin | also known as pyrazomycin, potent inhibitor | Methanothermobacter thermautotrophicus | |
pyrazofurin | also known as pyrazomycin, potent inhibitor | Plasmodium falciparum | |
pyrazofurin | also known as pyrazomycin, potent inhibitor | Saccharomyces cerevisiae | |
pyrazofurin | also known as pyrazomycin, potent inhibitor | Staphylococcus aureus | |
pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Helicobacter pylori | |
pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Homo sapiens | |
pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Methanothermobacter thermautotrophicus | |
pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Plasmodium falciparum | |
pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Saccharomyces cerevisiae | |
pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Staphylococcus aureus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0017 | - |
orotidine 5'-phosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Homo sapiens | |
0.0037 | - |
orotidine 5'-phosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Methanothermobacter thermautotrophicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | - |
- |
- |
Homo sapiens | - |
- |
- |
Methanothermobacter thermautotrophicus | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Staphylococcus aureus |
- |
Homo sapiens |
- |
Saccharomyces cerevisiae |
- |
Methanothermobacter thermautotrophicus |
- |
Helicobacter pylori |
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | - |
Staphylococcus aureus | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | - |
Saccharomyces cerevisiae | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | - |
Helicobacter pylori | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | - |
Plasmodium falciparum | UMP + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODCase | - |
Staphylococcus aureus |
ODCase | - |
Homo sapiens |
ODCase | - |
Saccharomyces cerevisiae |
ODCase | - |
Methanothermobacter thermautotrophicus |
ODCase | - |
Helicobacter pylori |
ODCase | - |
Plasmodium falciparum |
Orotidine-5'-monophosphate decarboxylase | - |
Staphylococcus aureus |
Orotidine-5'-monophosphate decarboxylase | - |
Homo sapiens |
Orotidine-5'-monophosphate decarboxylase | - |
Saccharomyces cerevisiae |
Orotidine-5'-monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
Orotidine-5'-monophosphate decarboxylase | - |
Helicobacter pylori |
Orotidine-5'-monophosphate decarboxylase | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000000009 | - |
barbiturate ribonucleoside 5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Saccharomyces cerevisiae | |
0.000005 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Saccharomyces cerevisiae | |
0.000017 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Homo sapiens | |
0.00013 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Helicobacter pylori | |
0.0062 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Methanothermobacter thermautotrophicus | |
9.1 | - |
5-cyano-UMP | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Plasmodium falciparum | |
290 | - |
5-cyano-UMP | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Helicobacter pylori | |
550 | - |
5-cyano-UMP | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Staphylococcus aureus |