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Literature summary for 4.1.1.23 extracted from

  • Sievers, A.; Wolfenden, R.
    The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase (2005), Bioorg. Chem., 33, 45-52.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of mutant enzymes C155S and D96A/C155S in Escherichia coli Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
C155S more stable than wild-type enzyme Saccharomyces cerevisiae
D96A/C155S inactive mutant protein Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
6-hydroxy UMP inhibits activity with orotidine and orotidine 5'-phosphate, mutant enzyme C155S Saccharomyces cerevisiae
Barbituric acid mutant enzyme C155S Saccharomyces cerevisiae
Orotidine mutant enzyme C155S Saccharomyces cerevisiae
phosphate competitive, mutant enzyme C155S Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0007
-
Orotidine pH 7.2, 23°C, mutant enzyme C155S Saccharomyces cerevisiae
30
-
orotidine 5'-phosphate value is higher than 30 mM, pH 7.2, 23°C, mutant enzyme C155S Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
orotidine low decarboxylation activity Saccharomyces cerevisiae uridine + CO2
-
?
Orotidine 5'-phosphate
-
Saccharomyces cerevisiae UMP + CO2
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.000007
-
orotidine 5'-phosphate pH 7.2, 23°C, mutant enzyme C155S Saccharomyces cerevisiae
22
-
Orotidine pH 7.2, 23°C, mutant enzyme C155S Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.7
-
phosphate mutant enzyme C155S Saccharomyces cerevisiae