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Literature summary for 4.1.1.23 extracted from
- Orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum (2004), Biochem. Biophys. Res. Commun., 318, 1012-1018.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-fluoro-UMP | - |
Plasmodium falciparum |  |
| 6-aza-UMP | - |
Plasmodium falciparum | |
| UMP | - |
Plasmodium falciparum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0032 | - |
orotidine 5'-phosphate | pH 8.0, 37°C | Plasmodium falciparum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14000 | - |
multienzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase with two subunits each of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase | Plasmodium falciparum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Orotidine 5'-phosphate | Plasmodium falciparum | the sixth enzyme in the pathway catalyzing formation of uridine 5'-monophosphate | UMP + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Plasmodium falciparum |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5.625 | - |
- |
Plasmodium falciparum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Orotidine 5'-phosphate | the sixth enzyme in the pathway catalyzing formation of uridine 5'-monophosphate | Plasmodium falciparum | UMP + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| multimer | orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase form a multienzyme complex with two subunits each of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase (38000 Da per subunit, determined by SDS-PAGE) | Plasmodium falciparum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OMPDC | - |
Plasmodium falciparum |
| Orotidine 5'-monophosphate decarboxylase | - |
Plasmodium falciparum |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 15.6 | - |
orotidine 5'-phosphate | pH 8.0, 37°C | Plasmodium falciparum | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
UMP | - |
Plasmodium falciparum | |
| 0.14 | - |
6-aza-UMP | - |
Plasmodium falciparum | |
| 0.67 | - |
5-fluoro-UMP | - |
Plasmodium falciparum | |
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