Any feedback?
Literature summary for 4.1.1.23 extracted from
- Interconversion of different molecular weight forms of human erythrocyte orotidylate decarboxylase (1975), J. Biol. Chem., 250, 7352-7358.
General Stability
| General Stability | Organism |
|---|---|
| conversion of the monomer to higher molecular weight forms is associated with increased stability | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| potassium phosphate | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0006 | - |
orotidine 5'-phosphate | tetrameric enzyme form | Homo sapiens | |
| 0.003 | - |
orotidine 5'-phosphate | dimeric enzyme form | Homo sapiens | |
| 0.025 | - |
orotidine 5'-phosphate | monomeric enzyme form | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
monomeric enzyme form, gel filtration | Homo sapiens |
| 115000 | - |
dimeric enzyme form, gel filtration | Homo sapiens |
| 250000 | - |
tetrameric enzyme form, gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0017 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, storage of the high molecular weight forms in presence of 0.15 mM oxipurinol prevents the spontaneous dissociation which occures when these forms are stored in 50 mM potassium phosphate, pH 7.4 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
1 min: 60% loss of the activity of the monomeric form, 10% loss of activity of the tetrameric form | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
