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Literature summary for 4.1.1.19 extracted from

  • Hernandez, S.; Schwarcz de Tarlovsky, S.
    Arginine decarboxylase in Trypanosoma cruzi, characteristics and kinetic properties (1999), Cell. Mol. Biol., 45, 383-391.
    View publication on PubMed
Search for more literature for 4.1.1.19

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol absolute requirement Trypanosoma cruzi
DL-alpha-difluoromethylornithine activates Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
DL-alpha-difluoromethylarginine
-
 Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
 L-Arg double reciprocal plot is biphasic with a Km-value of 10 mM at higher concentrations of L-Arg Trypanosoma cruzi

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-
Trypanosoma cruzi RA
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote enzyme activity is only present in the early stage of the parasite exponential growth, between 4 and 23 h of cultivation in presence of Arg, with a maximum at 14 h and disappears completely at the mid logarithmic phase. It is never detected during the stationary phase Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Trypanosoma cruzi agmatine + CO2
-
 ?
L-arginine
-
 Trypanosoma cruzi RA agmatine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ADC
-
 Trypanosoma cruzi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
-
 Trypanosoma cruzi

pH Stability

pH Stability pH Stability Maximum Comment Organism
7.9
-
 maximal activity Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate absolute requirement Trypanosoma cruzi