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Literature summary for 4.1.1.17 extracted from

  • Boitz, J.M.; Yates, P.A.; Kline, C.; Gaur, U.; Wilson, M.E.; Ullman, B.; Roberts, S.C.
    Leishmania donovani ornithine decarboxylase is indispensable for parasite survival in the mammalian host (2009), Infect. Immun., 77, 756-763.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development pharmacological inhibition of ODC is a promising therapeutic paradigm for the treatment of visceral and perhaps other forms of leishmaniasis Leishmania donovani
pharmacology pharmacological inhibition of ODC is a promising therapeutic paradigm for the treatment of visceral and perhaps other forms of leishmaniasis Leishmania donovani

Protein Variants

Protein Variants Comment Organism
additional information construction of conditionally lethal DELTAodc null mutants by double targeted gene replacement within a virulent strain. Parasitemias of DELTAodc null mutants are reduced by 6 and 3 orders of magnitude, respectively, in livers and spleens of BALB/c mice showing compromised infectivity phenotypes, overview. Nutritional phenotypes and Survival of DELTAodc parasites in peritoneal macrophages, overview Leishmania donovani

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine a suicide inhibitor of ODC, inhibits growth of wild-type Leishmania donovani amastigotes and effectively cures macrophages of parasites, thereby preventing host cell destruction Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Leishmania donovani rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes putrescine + CO2
-
?
L-ornithine Leishmania donovani LdBob rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes putrescine + CO2
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?

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-
Leishmania donovani LdBob
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote from livers and spleens of BALB/c mice Leishmania donovani
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promastigote from livers and spleens of BALB/c mice Leishmania donovani
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Leishmania donovani putrescine + CO2
-
?
L-ornithine rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes Leishmania donovani putrescine + CO2
-
?
L-ornithine
-
Leishmania donovani LdBob putrescine + CO2
-
?
L-ornithine rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes Leishmania donovani LdBob putrescine + CO2
-
?

Synonyms

Synonyms Comment Organism
ODC
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Leishmania donovani