Application | Comment | Organism |
---|---|---|
drug development | pharmacological inhibition of ODC is a promising therapeutic paradigm for the treatment of visceral and perhaps other forms of leishmaniasis | Leishmania donovani |
pharmacology | pharmacological inhibition of ODC is a promising therapeutic paradigm for the treatment of visceral and perhaps other forms of leishmaniasis | Leishmania donovani |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of conditionally lethal DELTAodc null mutants by double targeted gene replacement within a virulent strain. Parasitemias of DELTAodc null mutants are reduced by 6 and 3 orders of magnitude, respectively, in livers and spleens of BALB/c mice showing compromised infectivity phenotypes, overview. Nutritional phenotypes and Survival of DELTAodc parasites in peritoneal macrophages, overview | Leishmania donovani |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylornithine | a suicide inhibitor of ODC, inhibits growth of wild-type Leishmania donovani amastigotes and effectively cures macrophages of parasites, thereby preventing host cell destruction | Leishmania donovani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Leishmania donovani | rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes | putrescine + CO2 | - |
? | |
L-ornithine | Leishmania donovani LdBob | rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes | putrescine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Leishmania donovani LdBob | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | from livers and spleens of BALB/c mice | Leishmania donovani | - |
promastigote | from livers and spleens of BALB/c mice | Leishmania donovani | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Leishmania donovani | putrescine + CO2 | - |
? | |
L-ornithine | rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes | Leishmania donovani | putrescine + CO2 | - |
? | |
L-ornithine | - |
Leishmania donovani LdBob | putrescine + CO2 | - |
? | |
L-ornithine | rate-limiting enzyme in polyamine biosynthesis. ODC is an essential cellular determinant necessary for the viability and growth of both Leishmania donovani promastigotes and amastigotes | Leishmania donovani LdBob | putrescine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Leishmania donovani |