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Literature summary for 4.1.1.12 extracted from

  • Wong, P.T.H.
    Rat brain aspartate beta-decarboxylase. A comparative study with the liver enzyme (1985), Neurochem. Int., 7, 351-355.
    View publication on PubMed
Search for more literature for 4.1.1.12

Activating Compound

Activating Compound Comment Organism Structure
Ser acticates liver enzyme, competitively inhibits kidney and brain enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ala liver enzyme Rattus norvegicus
Aminooxyacetate
-
 Rattus norvegicus
beta-Ala liver enzyme Rattus norvegicus
Cys liver enzyme Rattus norvegicus
Gln liver enzyme Rattus norvegicus
Glu liver enzyme Rattus norvegicus
Ser activates liver enzyme, competitively inhibits kidney and brain enzyme Rattus norvegicus
Val weak, liver enzyme Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3
-
 L-Asp brain enzyme Rattus norvegicus
3.5
-
 L-Asp liver and kidney enzyme Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain highest activity in the cortex, lowest activity in the striatum and hippocampus Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Asp
-
 Rattus norvegicus L-Ala + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1 7.4
-
 Rattus norvegicus
7.4
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.7 8.1 about 60% of maximal activity at pH 5.7 and pH 8.1 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate firmly bound cofactor Rattus norvegicus