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Literature summary for 4.1.1.11 extracted from

  • Stuecker, T.; Tucker, A.; Escalante-Semerena, J.
    PanM, an acetyl-coenzyme a sensor required for maturation of L-aspartate decarboxylase (PanD) (2012), mBio, 3, e00158-12.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation with the CoA-binding-deficient PanMG76L variant Salmonella enterica
PanM Salmonella enterica PanM, formerly YhhK, a Gcn5-like N-acetyltransferase, is necessary for pro-PanD maturation, both in vitro and in vivo. PanM-dependent pro-PanD maturation does not involve an acetyl transfer event. CoA binding to PanM is needed for in vivo activity, disruption of CoA binding prevents PanM from interacting with PanD. PanM lacks acetyltransferase activity but functions instead as an acetyl-coenzyme A (CoA) sensor, overview Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate Salmonella enterica
-
beta-alanine + CO2
-
?
L-aspartate Salmonella enterica DM10310
-
beta-alanine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
serovar Typhimurium LT2, gene panD
-
Salmonella enterica DM10310
-
serovar Typhimurium LT2, gene panD
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification PanD is a pyruvoyl enzyme that is synthesized by the cell as an inactive precursor, pro-PanD. Maturation of pro-PanD into PanD occurs via a self-cleavage event at residue Ser25, which forms the catalytic pyruvoyl moiety. Salmonella enterica PanM, a Gcn5-like N-acetyltransferase, is necessary for pro-PanD maturation, both in vitro and in vivo Salmonella enterica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate
-
Salmonella enterica beta-alanine + CO2
-
?
L-aspartate
-
Salmonella enterica DM10310 beta-alanine + CO2
-
?

Synonyms

Synonyms Comment Organism
PanD
-
Salmonella enterica