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Literature summary for 4.1.1.11 extracted from
- Purification and properties of L-aspartate-alpha-decarboxylase, an enzyme that catalyzes the formation of beta-alanine in Escherichia coli (1979), J. Biol. Chem., 254, 8074-8082.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Pyruvoyl group | 1 mol of pyruvate is covalently bound per mol of enzyme | Escherichia coli |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| beta-hydroxy-DL-Asp | - |
Escherichia coli | |
| CuCl | 10 mM, 88% inhibition | Escherichia coli | |
| D-Ser | - |
Escherichia coli | |
| hydroxylamine | - |
Escherichia coli | |
| KCl | 200 mM, 63% inhibition | Escherichia coli | |
| L-cysteic acid | - |
Escherichia coli | |
| L-Glu | - |
Escherichia coli | |
| L-Ser | - |
Escherichia coli | |
| NaBH4 | - |
Escherichia coli | |
| oxaloacetate | - |
Escherichia coli | |
| phenylhydrazine | - |
Escherichia coli | |
| succinate | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.16 | - |
L-Asp | - |
Escherichia coli | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | - |
gel filtration | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli B / ATCC 11303 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.65 | - |
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Aspartate | - |
Escherichia coli | beta-Ala + CO2 | - |
? | |
| L-Aspartate | - |
Escherichia coli B / ATCC 11303 | beta-Ala + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
- |
Escherichia coli |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 26 | 78 | half-maximal activity at 26°C and at 78°C | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | - |
Escherichia coli |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.3 | 8.6 | half-maximal activity at pH 5.3 and at pH 8.6 | Escherichia coli |
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