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Literature summary for 3.6.5.2 extracted from

  • Lopez, J.A.; Kwan, E.P.; Xie, L.; He, Y.; James, D.E.; Gaisano, H.Y.
    The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells (2008), J. Biol. Chem., 283, 17939-17945.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
AS28N the mutant significantly inhibits KCl-induced insulin secretion but has no significant effect on glucose/carbachol-and glucose/KCl-induced insulin secretion despite an inhibitory trend Mus musculus
AS28N the mutant significantly inhibits KCl-induced insulin secretion but has no significant effect on glucose/carbachol-and glucose/KCl-induced insulin secretion despite an inhibitory trend Rattus norvegicus
G23V RalA mutant with higher affinity for GTP Mus musculus
G23V RalA mutant with higher affinity for GTP Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information RalA localizes independently of intracellular insulin granules Mus musculus
-
-
additional information RalA localizes independently of intracellular insulin granules Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus RalA is a critical component in biphasic insulin release from pancreatic beta cells ?
-
?
additional information Rattus norvegicus RalA is a critical component in biphasic insulin release from pancreatic beta cells ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose bead chromatography Mus musculus
glutathione-Sepharose bead chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 cell
-
Rattus norvegicus
-
MIN-6 cell
-
Mus musculus
-
pancreatic islet beta cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RalA is a critical component in biphasic insulin release from pancreatic beta cells Mus musculus ?
-
?
additional information RalA is a critical component in biphasic insulin release from pancreatic beta cells Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
RalA
-
Mus musculus
RalA
-
Rattus norvegicus