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Literature summary for 3.6.5.2 extracted from

  • Lu, Q.; Longo, F.M.; Zhou, H.; Massa, S.M.; Chen, Y.H.
    Signaling through Rho GTPase pathway as viable drug target (2009), Curr. Med. Chem., 16, 1355-1365.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
additional information Rho kinase is an important downstream effector of RhoA GTPases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
atorvastatin marketed as Lipitor, i.e. [R-(R*,R*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, inhibits RhoA activity by reducing Rho geranylgeranylation Homo sapiens
CCG-1423
-
 Homo sapiens
CCG-977
-
 Homo sapiens
cerivastatin marketed as Baycol/Lipobay, i.e. (E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyridin-3-yl]-3,5-dihydroxy-hept-6-enoic acid, RhoA inhibitor Homo sapiens
lovastatin marketed as Mevacor, i.e. 8-[2-(4-hydroxy-6-oxo-oxan-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-[hexahydronaphthalen-1-yl]2-methylbutanoate Homo sapiens
NSC23766 not very potent inhibitor of Rac1 and Cdc42 Homo sapiens
simvastatin marketed as Zocor, i.e. [(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]3.7-dimethyl]-1,2,3,7,8,8a-[hexahydronaphthalen-1-yl]2,2-dimethylbutanoate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroleukemia cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Cdc42
-
 Homo sapiens
Rac1
-
 Homo sapiens
Rho GTPase
-
 Homo sapiens
RhoA
-
 Homo sapiens