Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | some of the amino acids that are crucial for GTPase activity are mutated in RhoH so that the protein is a GTPase-deficient, so-called atypical Rho GTPase. Other mechanisms of regulating RhoH activity include regulation at the mRNA level and tyrosine phosphorylation of the protein's unique ITAM-like motif. The C-terminal CaaX box of RhoH is mainly a target for farnesyl-transferase but can also be modified by geranylgeranyltransferase. Isoprenylation of RhoH and changes in subcellular localisation may be an additional factor to fine-tune signalling | Mus musculus | |
additional information | some of the amino acids that are crucial for GTPase activity are mutated in RhoH so that the protein is a GTPase-deficient, so-called atypical Rho GTPase. Other mechanisms of regulating RhoH activity include regulation at the mRNA level and tyrosine phosphorylation of the protein's unique ITAM-like motif. The C-terminal CaaX box of RhoH is mainly a target for farnesyl-transferase but can also be modified by geranylgeranyltransferase. Isoprenylation of RhoH and changes in subcellular localisation may be an additional factor to fine-tune signalling | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | neither the overall survival nor the disease-free survival rate in diffuse large B-cell lymphoma can be linked to hypermutation of the RHOH gene | Mus musculus |
medicine | neither the overall survival nor the disease-free survival rate in diffuse large B-cell lymphoma can be linked to hypermutation of the RHOH gene | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
membrane | only the membrane-localised form of RhoH is able to downregulate Rac1 efficiently | Mus musculus | 16020 | - |
membrane | only the membrane-localised form of RhoH is able to downregulate Rac1 efficiently | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity | ? | - |
? | |
additional information | Homo sapiens | RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity | ? | - |
? | |
additional information | Mus musculus | the small GTPase RhoH is an atypical regulator of haematopoietic cells | ? | - |
? | |
additional information | Homo sapiens | the small GTPase RhoH is an atypical regulator of haematopoietic cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15669 | - |
- |
Mus musculus | Q9D3G9 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | the CKIF motif in human RhoH is a target for the in vitro modification by farnesyl-transferase and geranylgeranyl-transferase | Homo sapiens |
additional information | the CKIF motif in mouse RhoH is a target for the in vitro modification by farnesyl-transferase and geranylgeranyl-transferase | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hematopoietic cell | RhoH is specifically expressed in hematopoietic cells | Mus musculus | - |
hematopoietic cell | RhoH is specifically expressed in hematopoietic cells | Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
additional information | RhoH is underexpressed in hairy cell leukaemia and acute myeloid leukaemia cells | Homo sapiens | - |
NIH-3T3 cell | - |
Mus musculus | - |
T-lymphocyte | RhoH is expressed strongest in T-lymphocytes and acts as a positive regulatory factor for thymocyte selection and T-cell receptor signalling | Mus musculus | - |
T-lymphocyte | RhoH is expressed strongest in T-lymphocytes and acts as a positive regulatory factor for thymocyte selection and T-cell receptor signalling | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity | Mus musculus | ? | - |
? | |
additional information | RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity | Homo sapiens | ? | - |
? | |
additional information | the small GTPase RhoH is an atypical regulator of haematopoietic cells | Mus musculus | ? | - |
? | |
additional information | the small GTPase RhoH is an atypical regulator of haematopoietic cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RhoH | initially named translation three four, RhoH is a GTPase-deficient so-called atypical Rho GTPase, RhoH is only found in vertebrates | Mus musculus |
RhoH | initially named translation three four, RhoH is a GTPase-deficient so-called atypical Rho GTPase, RhoH is only found in vertebrates | Homo sapiens |