Literature summary for 3.6.5.2 extracted from

Spencer, A.G.; Orita, S.; Malone, C.J.; Han, M.
A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans (2001), Proc. Natl. Acad. Sci. USA, 98, 13132-13137.

Search for more literature for 3.6.5.2

Activating Compound

Activating Compound	Comment	Organism	Structure
UNC-73	Trio-like guanine nucleotide exchange factor encoded by unc-73, acts as an activator of RHO-1 in the migration process, the UNC-73 GEF2 domain may have the exchange activity on RHO-1 in vivo	Caenorhabditis elegans

Cloned(Commentary)

Cloned (Comment)	Organism
T19N and G14V mutant rho-1 cDNA	Caenorhabditis elegans

Protein Variants

Protein Variants	Comment	Organism
G14V	constitutively active or gain of function	Caenorhabditis elegans
additional information	eliminating or reducing rho-1 gene function by using a dominant-negative transgene or dsRNA interference results in a severe defect in migration of hypodermal P cells to a ventral position	Caenorhabditis elegans
T19N	dominant negative mutation, phenotype	Caenorhabditis elegans

Inhibitors

Inhibitors	Comment	Organism	Structure
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine	Rho toxin from Clostridium botulinum, ADP-ribosylates and specifically inactivates rho-1	Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Caenorhabditis elegans	RHO-1 plays a role in hypodermal P cell migration to a ventral position during larval development	GDP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	wild-type strain N2 Bristol	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Caenorhabditis elegans	GDP + phosphate	-	?
GTP + H2O	RHO-1 plays a role in hypodermal P cell migration to a ventral position during larval development	Caenorhabditis elegans	GDP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
RHO-1	RhoA GTPase homologue	Caenorhabditis elegans

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Release 2023.1 (January 2023)