Cloned (Comment) | Organism |
---|---|
Rab21 cDNA from K-562 cell, expression in HeLa cells CCL-2 and in hepatocellular carcinoma Hep3B cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Q78L | mutant is defective in GTP hydrolysis, subcellular distribution | Homo sapiens |
T33N | mutant enzyme is defective in GTP binding, cells expressing mutant Rab21 show defects in endocytosis of transferrin and epidermal growth factor and fail to effectively deliver the latter ligand to late endosomes and lysosomes for degradation, subcellular distribution | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endocytic vesicle | Rab21 is predominantly localized to the early endocytic pathway, on vesicles containing early-endosomal antigen 1, transferrin receptor and internalized ligands | Homo sapiens | 30139 | - |
additional information | subcellular distribution of wild-type, T33N and Q78L mutant Rab21 | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51000 | - |
x * 51000, GFP-Rab21, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Homo sapiens | Rab21 has a role in the dynamics of the early endocytic pathway | GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UL25 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
K-562 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | Rab21 has a role in the dynamics of the early endocytic pathway | Homo sapiens | GDP + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 51000, GFP-Rab21, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Rab21 | - |
Homo sapiens |