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Literature summary for 3.6.5.2 extracted from

  • Wennerberg, K.; Der, C.J.
    Rho-family GTPases: It's not only Rac and Rho (and I like it) (2004), J. Cell Sci., 117, 1301-1312.
    View publication on PubMed
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
additional information regulation of Cdc42 activity Homo sapiens
additional information regulation of Rac1 activity Homo sapiens
additional information regulation of RhoA activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information regulation of Cdc42 activity; regulation of Rac1 activity; regulation of RhoA activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens Cdc42 causes formation of filopodia, which might be involved in the recognition of the extracellular environment GDP + phosphate
-
 ?
GTP + H2O Homo sapiens Rac1 promotes actin polymerization and the formation of lamellipodia of migrating cells GDP + phosphate
-
 ?
GTP + H2O Homo sapiens RhoA promotes actin-myosin contractility and, thereby, the formation of stress fibers and focal adhesions, regulating cell shape, attachment and motility GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification contains a geranylgeranyl prenylation motif Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information ubiquitous expression pattern Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
GTP + H2O Cdc42 causes formation of filopodia, which might be involved in the recognition of the extracellular environment Homo sapiens GDP + phosphate
-
 ?
GTP + H2O Rac1 promotes actin polymerization and the formation of lamellipodia of migrating cells Homo sapiens GDP + phosphate
-
 ?
GTP + H2O RhoA promotes actin-myosin contractility and, thereby, the formation of stress fibers and focal adhesions, regulating cell shape, attachment and motility Homo sapiens GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Cdc42 member of the Rho-family Homo sapiens
Rac1 member of the Rho-family Homo sapiens
RhoA member of the Rho-family Homo sapiens