Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Rac-specific GEF Tiam1 | activates Rac3, but less efficiently than the Rac isoform Rac2 | Homo sapiens | |
Rac-specific GEF Tiam1 | stimulates the GDP exchange reaction, increases the GDP dissociation rate, activates Rac1 less efficiently than Rac2 | Homo sapiens | |
Rac-specific GEF Tiam1 | stimulates the GDP exchange reaction, increases the GDP dissociation rate, activates Rac2 more efficiently than the Rac isoforms Rac1 and Rac3 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
Rac1, expression in Escherichia coli as glutathione S-transferase fusion protein | Homo sapiens |
Rac2, expression in Escherichia coli as glutathione S-transferase fusion protein | Homo sapiens |
Rac3, expression in Escherichia coli as glutathione S-transferase fusion protein | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p21 activated kinase | PAK, inhibits nucleotide dissociation from enzyme; PAK, inhibits nucleotide dissociation from enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | nucleotide association and dissociation kinetics | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Homo sapiens | Rac1 regulates gene expression, cell cycle progression and rearrangement of the actin cytoskeleton, Rac1 is ubiquitously expressed and regulates a wide variety of cellular processes | GDP + phosphate | - |
? | |
GTP + H2O | Homo sapiens | Rac2 may be responsible for the regulation of the oxidative burst in hematopoietic cells | GDP + phosphate | - |
? | |
GTP + H2O | Homo sapiens | Rac3 is ubiquitously expressed and regulates a wide variety of cellular processes | GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P60763 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant Rac1 | Homo sapiens |
recombinant Rac2 | Homo sapiens |
recombinant Rac3 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hematopoietic cell | Rac2 is predominantly expressed in cells of the hematopoietic lineage | Homo sapiens | - |
additional information | Rac1 is ubiquitously expressed | Homo sapiens | - |
additional information | Rac3 is ubiquitously expressed | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Rac1 regulates gene expression, cell cycle progression and rearrangement of the actin cytoskeleton, Rac1 is ubiquitously expressed and regulates a wide variety of cellular processes | Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | Rac2 may be responsible for the regulation of the oxidative burst in hematopoietic cells | Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | Rac3 is ubiquitously expressed and regulates a wide variety of cellular processes | Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | nucleotide binding and hydrolysis properties, comparison with the properties of the Rac isoforms Rac1 and Rac2 | Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | nucleotide binding and hydrolysis properties, comparison with the properties of the Rac isoforms Rac1 and Rac3, Rac2 structure, altered dynamics of Rac2 at the switch I region may be responsible for the differing biochemical properties compared with Rac1 and 3 | Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | nucleotide binding and hydrolysis properties, comparison with the properties of the Rac isoforms Rac2 and Rac3, enzyme structure | Homo sapiens | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rac1 | - |
Homo sapiens |
Rac2 | - |
Homo sapiens |
Rac3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |