Application | Comment | Organism |
---|---|---|
medicine | potential target for cancer therapeutics | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
complete coding sequence of ARL9, from testis, maps to chromosome 4q12 | Homo sapiens |
complete coding sequence of RASL11A, from prostate, maps to chromosome 13q12.2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | RASL11A is down-regulated in prostate tumors and may have a tumor suppressor role in prostate cancer | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6T310 | two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb | - |
Homo sapiens | Q6T311 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
GTP + H2O = GDP + phosphate | a family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase, EC 3.6.1.46, they are involved in cell-growth regulation, Ras subfamily, membrane vesicle traffic and uncoating, Rab and ARF subfamilies, nuclear protein import, Ran subfamily, and organization of the cytoskeleton, Rho and Rac subfamilies | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb | Homo sapiens | - |
colon | two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb | Homo sapiens | - |
additional information | the RASL11A transcript is ubiquitously expressed in human tissues, no expression in thymus and leukocytes | Homo sapiens | - |
ovary | very weak expression of RASL11A | Homo sapiens | - |
prostate | adjacent, two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb, the abundance of the RASL11A transcript is diminished in prostate tumors in comparison to normal adjacent prostate tissue | Homo sapiens | - |
testis | - |
Homo sapiens | - |
testis | two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
additional information | RASL11A is down-regulated in prostate tumors and may have a tumor suppressor role in prostate cancer | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Arl9 | ADP-ribosylation factor-like 9 | Homo sapiens |
More | member of a novel small monomeric GTPase gene family | Homo sapiens |
Rasl11a | RAS-like, family 11, member A | Homo sapiens |