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Literature summary for 3.6.5.2 extracted from

  • Jones, S.; Litt, R. J.; Richardson, C.J.; Segev, N.
    Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport (1995), J. Cell Biol., 130, 1051-1061.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
guanine nucleotide exchange factor GEF facilitates loading with GTP Homo sapiens
guanine nucleotide exchange factor GEF facilitates loading with GTP Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
D124N Ypt1, changed nucleotide specificity from guanine to xanthine, complete inhibition of guanosine nucleotide exchange factor-mediated nucleotide exchange Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ir
GTP + H2O Saccharomyces cerevisiae
-
 GDP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Saccharomyces cerevisiae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ir
GTP + H2O
-
 Saccharomyces cerevisiae GDP + phosphate
-
 ir

Synonyms

Synonyms Comment Organism
Ypt1 Rab transport GTpase Saccharomyces cerevisiae