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Literature summary for 3.6.5.2 extracted from

  • Geyer, M.; Wittinghofer, A.
    GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding protein (1997), Curr. Opin. Struct. Biol., 7, 786-792.
    View publication on PubMed
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
GTPase activating protein GAP for Ras-related proteins, stimulates intrinsic GTPase reaction Homo sapiens
GTPase activating protein GAP for Ras-related proteins, stimulates intrinsic GTPase reaction Bos taurus
GTPase activating protein GAP for Ras-related proteins, stimulates intrinsic GTPase reaction Rattus sp.
guanine nucleotide exchange factor GEF facilitates loading with GTP Homo sapiens
guanine nucleotide exchange factor GEF facilitates loading with GTP Bos taurus
guanine nucleotide exchange factor GEF facilitates loading with GTP Rattus sp.

Crystallization (Commentary)

Crystallization (Comment) Organism
Arf1 complexed to GDP, common G domain topology Homo sapiens
Arf1, complexed to GDP, common G domain topology Rattus sp.
Rac1, active conformation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
guanine nucleotide dissociation inhibitor GDI
-
 Bos taurus
guanine nucleotide dissociation inhibitor GDI down-regulating GTPase activity, inhibition of nucleotide dissociation Homo sapiens
guanine nucleotide dissociation inhibitor GDI down-regulating GTPase activity, inhibition of nucleotide dissociation Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP GDP + phosphate
-
 ir
GTP + H2O Bos taurus increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP GDP + phosphate
-
 ir
GTP + H2O Rattus sp. increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP GDP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Rattus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP Homo sapiens GDP + phosphate
-
 ir
GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP Bos taurus GDP + phosphate
-
 ir
GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP Rattus sp. GDP + phosphate
-
 ir
GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP Homo sapiens GDP + phosphate
-
 ir
GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP Bos taurus GDP + phosphate
-
 ir
GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP Rattus sp. GDP + phosphate
-
 ir

Synonyms

Synonyms Comment Organism
Arf 1
-
 Homo sapiens
Arf 1
-
 Rattus sp.
Rac1 Rho subfamily Homo sapiens
Rac1 Rho subfamily Bos taurus
Ran Ras-related, participating in nucleocytoplasmatic transport Homo sapiens
RAS
-
 Homo sapiens
RAS
-
 Bos taurus
RAS
-
 Rattus sp.