Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Pasteurella multocida toxin | - |
Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Q209E | increase of enzyme activity | Mus musculus |
Q209L | increase of enzyme activity | Mus musculus |
R183C | increase of enzyme activity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Pasteurella multocida toxin | deamidates glutamine-205 of G alphaI2 to glutamic acid, inhibits intrinsic GTPase activity, causes persistent activation of the G protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
MEF cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | assay at pH 7.5, 15 mM MgCl | Homo sapiens | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G alpha i2 | - |
Homo sapiens |
G alpha q | - |
Mus musculus |
heterotrimeric G protein | - |
Mus musculus |
heterotrimeric G protein | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |